Maspin hendrix mary. Biological functions of maspin, Journal of Cellular Physiology 2019-02-01

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Maspin: molecular mechanisms and therapeutic implications

maspin hendrix mary

Archived from on 10 February 2011. These studies uncover a novel mechanism of Tbx3 regulation and identify a new target of the tumour suppressor miR-206. Subsequent functional analyses revealed the stimulatory effect of this fragment on the migratory and invasive capability of E-cadherin-positive cells. Here she performed wartime research on the growth of tomato seedlings and received a master's degree in 1944. The documented role of both P 1 and P 1 ' highlights the importance of S 1 'P 1 ' interactions in enzyme-inhibitor complexes.

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Maspin (Book, 2002) [browsertap.com]

maspin hendrix mary

Next, we examined the effect of miR-125b on CaP cell proliferation. Increased focal adhesions and stress fibers were observed after 12 h of rMaspin treatment, when the cells were least motile and had reverted to a more epithelial-like phenotype. Jorcano, Ana Bravo, Ángel Ramírez, M. Sager changed her research focus to cancer biology in the 1970s, with a specific focus on , and spent time researching at London's Imperial Cancer Research Fund Laboratory from 1972-1973, where she met her future husband,. Acknowledgments This work was supported by a grant from the National Institutes of Health to M. The loop then undergoes a conformational change to the relaxed state irreversibly trapping the protease in an inactive state. The mechanisms that regulate Tbx3 expression in cancer have not been fully explored.

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Ruth Sager

maspin hendrix mary

This research provided evidence for non-Mendelian uniparental inheritance; it also showed that there are multiple independent genetic systems in Chlamydomonas. Accordingly, the molecular function of maspin remains unclear. When compared with the control, miR-125b treatment increased clonogenic survival of CaP cells, while anti-miR-125b caused a dramatic reduction in the number of colonies. Odero-Marah, Jianchun Xu, Haiyen E. These new findings not only further enhance our understanding of cancer biology but also provide an avenue to develop maspin's potential as a diagnostic marker for cancer progression, and as a potentially powerful therapeutic agent in the fight against breast cancer.

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Sumaira Amir

maspin hendrix mary

New York: Oxford University Press. This protein belongs to the serine protease inhibitor superfamily. Odero-Marah, Zhila Khalkhali-Ellis, Galen B. Background The Tbx3 transcription factor is over-expressed in breast cancer, where it has been implicated in proliferation, migration and regulation of the cancer stem cell population. Following the war Sager had received her Ph. This unprecedented high discrimination between orthologous enzymes is postulated to derive from flexibility differences in the protein-protein interaction. This study provides new insights into the diverse signaling pathways affected by maspin to suppress the metastatic phenotype, and could contribute to novel therapeutic approaches for the treatment of invasive and metastatic breast cancer.

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Mrs. Mary Anne Hendrix

maspin hendrix mary

The precise molecular function of maspin is thus currently unknown. These data are consistent with the observation that maspin is not expressed in early embryogenesis. Hence the serpin functions as a of the protease. Her research there focused on the genetic and molecular causes of cancer, including investigation of the roles of , , and in tumor growth and spread. Main article: Maspin is a member of the serpin superfamily of serine protease inhibitors. These new findings not only further enhance our understanding of cancer biology but also provide an avenue to develop maspin's potential as a diagnostic marker for cancer progression, and as a potentially powerful therapeutic agent in the fight against breast cancer. Among the established anti-tumor effects of Maspin are the inhibition of cancer cell invasion, attachment to extracellular matrices, increased sensitivity to apoptosis, and inhibition of angiogenesis.

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Biological functions of maspin

maspin hendrix mary

. New York: Charles Scribner's Sons. However, while significant experimental data support the role of Maspin as a tumor suppressor, clinical data regarding the prognostic implications of Maspin expression have led to conflicting results. These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism. Odero-Marah, Sen Pathak, Asha Multani, Leland W.

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Maspin

maspin hendrix mary

Maspin is highly expressed in normal mammary epithelial cells but reduced or absent in aggressive breast carcinomas. Our results suggest that restoration of miR-206 in Tbx3-positive breast cancer could be exploited for therapeutic benefit. However, despite efforts to characterize the mechanism s by which maspin functions as a tumor suppressor, its molecular characterization has remained somewhat elusive. She was promoted to a staff position assistant in the biochemistry division in 1951, working in this capacity until 1955, using the alga as a model organism. Among the established anti-tumor effects of Maspin are the inhibition of cancer cell invasion, attachment to extracellular matrices, increased sensitivity to apoptosis, and inhibition of angiogenesis.

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Ruth Sager

maspin hendrix mary

However, to date no detailed molecular mechanism for maspin function in cell proliferation or tumour biology has been comprehensively described. However, while significant experimental data support the role of Maspin as a tumor suppressor, clinical data regarding the prognostic implications of Maspin expression have led to conflicting results. We provide insight into the immense therapeutic potential of Maspin and the challenges related to its successful clinical translation. Results In this study, we examined the regulation of Tbx3 by miR-206. Prasad, Gayatri Rath, Sandeep Mathur, Dinesh Bhatnagar and Ranju Ralhan, Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines , Chemico-Biological Interactions , 10. We examined the impact of miR-206 on Tbx3 expression in breast cancer cells using miR-206 mimic and inhibitor. However, while significant experimental data support the role of Maspin as a tumor suppressor, clinical data regarding the prognostic implications of Maspin expression have led to conflicting results.

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